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FDA Joins Tox21 Collaboration

The U.S. Food and Drug Administration (FDA) has joined the Tox21 collaboration, which leverages federal agency resources, including research, funding and testing tools, to develop models for more effective chemical risk assessments. The FDA is expected to provide additional expertise and chemical safety information to improve current chemical testing methods.

The collaboration, established in 2008, includes the U.S. Environmental Protection Agency (EPA), the National Institute of Environmental Health Sciences National Toxicology Program (NTP) and the National Institute of Health Chemical Genomics Center (NCGC) and now the FDA.

EPA says 2,000 chemicals have already been screened against dozens of biological targets. The group is targeting 10,000 chemicals screened by the end of the year.

FDA will collaborate with other Tox21 members to prioritize chemicals that need more extensive toxicological evaluation, and develop models that can better predict human response to chemicals.

EPA contributes to Tox21 through the ToxCast program and by providing chemicals and additional automated tests to NCGC. ToxCast currently includes 500 chemical screening tests that have assessed more 300 environmental chemicals.

A major part of the Tox21 partnership is the robotic screening and informatics platform at NCGC that uses fast, automated tests to screen thousands of chemicals a day for toxicological activity in cells, says EPA.

In April, the EPA launched its Web-based chemicals database, ToxRefDB, which allows anyone to search and download thousands of toxicity testing results on hundreds of chemicals. This latest announcement is part of the EPA’s policy to increase the transparency of chemical information.

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